Endocrine Abstracts

Clear cell renal carcinoma (CCRC) is a tumor with great metastatic capacity, although the presence of metastases in the thyroid gland is very uncommon. Therefore it is important to know the oncological background of the patient and to perform a complete immunohistochemical analysis of the thyroid lesion to obtain a correct diagnosis. Thyroidectomy can be considered in patients with no other metastasis or in those who present compressive symptoms as a palliative measure. We pre...

Autoimmune polyglandular syndromes (APS) are characterized by the association of two or more endocrine and/or nonendocrine autoimmune diseases with different immunologic features of their pathogenesis.Based on the clinical picture is divided into four different types. Type I APS comprises mucocutaneous candidiasis, hypoparathyroidism and Addison’s disease. Type II APS is defined by autoimmune Addison’s disease in association with chronic autoim...

Chronic autoimmune thyroiditis and Graves’ disease (GD) are two forms of autoimmune thyroid disease (AITD).The association of GD or other thyrotoxic forms of autoimmune thyroiditis with one or several toxic nodules is the Marine – Lenhart syndrome (SML). It is a rare pathology with prevalence between 2.7 and 4.1%. Its physiopathology remains complicated and misunderstood, incriminating antithyroidian auto-antibodies such as TSH re...

Introduction: Tertiary hyperparathyroidism (HPT) occurs most commonly in the setting of renal transplant where patients with secondary HPT continue to have elevated PTH levels after receiving a renal allograft. This disease is observed in up to 30% of kidney transplant recipients. This paper will include a case report and a review of epidemiology and pathophysiology, complications and clinical findings, indications for treatment, and the drugs currently available to treat this...

Introduction: The diagnosis of hyperparathyroidism can be challenging especially when surgery is mandatory and imaging techniques can not find the adenoma. PEt colina is a non-invasive diagnostic test that creates images of the parathyroid glands and detects abnormal activity. It is increasingly used and especially useful when there are no pathological findings in parathyroid scintigraphy.Methods: This is a retrospective observational study with data fro...

Pericentromeric inversion of the heterochromatic region of chromosome 9 has been reported in almost 4% of the cases of male infertility.Objective: Determining the karyotype from an infertile couple scheduled to perform IVF.Materials and methods: Slides with metaphasic chromosomes were GTG-banded according to standard protocol for cytogenetic analysis (karyotype). FISH analysis – inverted DAPI (4′-6-diamidino-2-phenylindo...

The aim of the study was to assess lipid status in subjects with hypothyroidism (overt and subclinical) and hyperthyroidism. Therefore, we analyzed the relationship between the levels of blood lipids (Lp(a), Apo AI, Apo B, Apo AI/B, total cholesterol (TC), triglyceride (TG), LDL, HDL, LDL) and TSH, FT4, T3, TPOAb concentration. The study groups included 38 subjects with overt hypothyroidism (mean±S.E.M., age 48.6±13.25 years), 30 ...

Objectives: To evaluate the effect of alendronate, alfacalcidol, and combinat agent of alendronate and alfacalcidol, in BMD change assess by Digital X-ray Radiogrammetry in postmenopausal women.Materials and methods: Nine thousand and two hundred and sixty four healthy women with ages between 20 and 89 years referred to our densitometry service using DXR-BMD. Six thousand and six hundred and twelve from these were in postmenopause. Using WHO-criteria for...

One of the clinical complications associated with the long term use of bisphosphonates treatment in osteoporosis is the atypical femoral fracture (AFF).Even the absolute risk is low and acceptable compared with the number of fractures prevented, there are still reasonable concerns due to the wide prescription of bisphosphonates and the existence of several case series proving that bisphosphonates have a strong association with this unique fracture type. We present a case of a ...

Introduction: Iron deficiency contributes to stabilization of HIF1α and upregulation of genes that stimulate angiogenesis in diseases associated with oxidative stress. The authors’ interest is centered on evaluation of the relation between iron status and angiogenesis (VEGF-A, sVEGFR) in patients with melanoma.Methods: The study included 128 patients with melanoma before surgical removal of the tumor. We determined ferritin (immunoturbidimetric...